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A beneficial effect of the tested substance on at least one of the cognitive domains was detected in 3 studies [13, 17, 19], 3 showed no effect [1416] and 1 showed a negative impact on the results of cognitive tests [18]

Trial-Reported Endpoints by Phase Trial Lancet 2021 Phase 2 Duration 26 weeks Population Overweight/obese, no T2D (n=706) Mean Weight Loss 10.8% at 4.5 mg vs 3.0% placebo Trial Lancet 2023 Phase 2 Duration 32 weeks Population T2D + obesity (n=92) Mean Weight Loss 8.1% cagrilintide alone

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